Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.
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منابع مشابه
Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.
The Zfy gene is located on the Y chromosome of placental mammals and encodes a zinc finger protein which may serve as the primary sex-determining signal. A related gene, Zfx, is similarly conserved on the X chromosome. Unlike that in most mammals, the mouse genome contains four homologous zinc finger loci: Zfy-1, Zfy-2, Zfx, and Zfa (on an autosome). We report that, in contrast to the mouse Zfy...
متن کاملComparison of human ZFY and ZFX transcripts.
ZFY is a candidate for the primary sex-determining gene (TDF, testis-determining factor) on the human Y chromosome. We have isolated cDNA clones of ZFY and its homologue on the X chromosome, ZFX. The transcripts of these genes are very similar to each other and encode predicted proteins of equal size. The conceptual amino acid sequence of both proteins contains an acidic domain, similar to the ...
متن کاملDifferential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus.
A comparative study of the last exon of the zinc finger genes Zfx, Zfy, and Zfa from species of mice in the genus Mus was conducted to assess the extent of gene-specific and chromosome-specific effects on the evolutionary patterns among related X-, Y-, and autosomal-linked genes. Phylogenetic analyses of 29 sequences from Zfx, Zfa, and Zfy from 10 taxa were performed to infer relatedness among ...
متن کاملThe sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers.
The ZFY gene, located in the sex-determining region of the human Y chromosome, appears to encode a zinc-finger protein. Two homologous genes, Zfy-1 and Zfy-2, are found in the sex-determining region of the mouse Y chromosome. One or both genes may serve as the primary sex-determining signal in mice. Both Zfy-1 and Zfy-2 are transcribed in the adult testis. Nucleotide sequence analysis of a Zfy-...
متن کاملCpG islands in human ZFX and ZFY and mouse Zfx genes: sequence similarities and methylation differences.
The human ZFX, human ZFY, and mouse Zfx genes have CpG islands near their 5; ends. These islands are typical in that they span about 1.5 kb, contain transcription initiation sites, and encompass some 5' untranslated exons and introns. However, comparitive nucleotide sequencing of these human and mouse islands provided evidence of evolutionary conservation to a degree unprecedented among mammali...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1990
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.10.2.681